<i>In vitro</i> antimicrobial evaluation of pyrazolone derivatives

Antimicrobial evaluation of indole-containing hydrazone derivatives.

There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in v...

Synthesis of pyrazolone derivatives and their biological activities

3-Methyl-1-phenylpyrazol-5-one and its derivatives prepared using ethyl acetoacetate, phenyl hydrazine and its derivatives. Ethyl acetoacetate reacted with phenylhydrazine at reflux temperature to give 3-methyl-1-phenylpyrazol-5-one crude and recrystlized from diluted ethanol to give pure 3-methyl1-phenylpyrazol-5-one. Different pyrazolone derivatives were prepared by using different phenyl hyd...

Synthesis of chloro pyrazolone derivatives and their biological activities

3-Methyl-5-chloro-1-phenylpyrazol and its derivatives were prepared by the reaction with 3methyl -1-phenylpyrazol-5-one, phosphorous oxytrichloride and N-N dimethyl aniline respectively using catalyst. These compounds were further treated with alcohols and sodium hydroxide to form ether linkage. Ethyl acetoacetate reacted with phenylhydrazine at reflux temprature to give 3-methyl-1phenylpyrazol...

Research concerning New Pyrazolone Derivatives with Biological Potential

of the PhD Thesis The Scientific Leader Prof.dr. Lenuţa PROFIRE

Synthesis , characterization and antimicrobial & antioxidant activity of 2 - Isonicotinoyl - 5 - methyl - 2 , 4 - dihydro - 3 H - pyrazolone derivatives